2. Signaling Pathways
  3. Epigenetics
  4. DNA Methyltransferase
  5. DNA Methyltransferase Degrader

DNA Methyltransferase Degrader

DNA Methyltransferase Isoform Comparison

DNA Methyltransferase Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-162282
    PROTAC METTL3-14 degrader 1
    		Degrader
    PROTAC METTL3-14 degrader 1 (compound 30) is a PROTAC degrader of METTL3-14. PROTAC METTL3-14 degrader 1 shows a 50% or higher degradation of METTL3 and/or METTL14(Pink: Ligand for target protein (HY-115717); Black: Linker (HY-168686); Blue: Ligand for E3 ligase (HY-10984)).
  • HY-173002
    MS9024
    		Degrader
    MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC50 of 35 nM (DC50 in MDA-MB-468 and H1299 is 254 nM and 101 nM). MS9024 also inhibits DNMT1 with an IC50 of 0.43 μM.